High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes
نویسندگان
چکیده
منابع مشابه
Changes in peripheral blood immune cell composition in osteoarthritis
OBJECTIVES Immune age-related abnormalities may synergise with osteoarthritis (OA) pathology. We explored whether abnormalities in the blood immune cell composition are present in OA, beyond defects typically associated with ageing. DESIGN Blood was collected from 121 healthy controls (HC) and 114 OA patients. Synovial biopsies were obtained from another 52 OA patients. Flow cytometry was use...
متن کاملHigh-dimensional single-cell analysis reveals the immune signature of narcolepsy
Narcolepsy type 1 is a devastating neurological sleep disorder resulting from the destruction of orexin-producing neurons in the central nervous system (CNS). Despite its striking association with the HLA-DQB1*06:02 allele, the autoimmune etiology of narcolepsy has remained largely hypothetical. Here, we compared peripheral mononucleated cells from narcolepsy patients with HLA-DQB1*06:02-matche...
متن کاملMethods for regression analysis in high-dimensional data
By evolving science, knowledge and technology, new and precise methods for measuring, collecting and recording information have been innovated, which have resulted in the appearance and development of high-dimensional data. The high-dimensional data set, i.e., a data set in which the number of explanatory variables is much larger than the number of observations, cannot be easily analyzed by ...
متن کاملPrevention of postsplenectomy sepsis.
The study of Hegarty et al. shows that two thirds of splenectomised patients are unaware of an increased risk of severe infectious diseases and cites nine recommendations to prevent severe infections. These data con®rm the ®ndings of several other studies. The Department of Haematology at Heinrich-HeineUniversity of DuÈ sseldorf has adopted an intense counselling attitude towards asplenic patie...
متن کاملClassification of high dimensional data: High Dimensional Discriminant Analysis
We propose a new method of discriminant analysis, called High Dimensional Discriminant Analysis (HHDA). Our approach is based on the assumption that high dimensional data live in different subspaces with low dimensionality. Thus, HDDA reduces the dimension for each class independently and regularizes class conditional covariance matrices in order to adapt the Gaussian framework to high dimensio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ImmunoHorizons
سال: 2020
ISSN: 2573-7732
DOI: 10.4049/immunohorizons.1900089